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Latest Drug Toxicity News


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Cancer Drugs Promote Therapy Resistant Colorectal Cancer  Voir?

Cancer drugs named MEK Inhibitors activates the cancer-promoting Wnt signalling pathway in colorectal cancer cells which could lead to the accumulation of cells with stem cell properties that are therapy resistant and have more tendency to relapse, discovered by scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Mannheim University Medical Center. Cells react to external influences via the biochemical reactions of the Wnt signalling pathway. Wnt ...

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New Drug Inhibit DNA Repair in Tumor Cells  Voir?

New Cancer drug found to inhibit certain tumor cells from repairing their own DNA. Combining this new drug named cediranib, with other agents could potentially target those tumors that uses specific pathways to create DNA repair cells, according to a study published in the journal iScience Translational Medicine/i. "There is a lot of interest in the cancer field in developing DNA repair inhibitors because they will greatly help treatments, like radiotherapy and chemotherapy, that aim to ...

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Weight Loss Medications Utilized Less by Eligible Veterans  Voir?

Weight management medicines were found to be used very less (about one percent) by eligible veterans despite their easy availability and clinical guidelines on their use for obesity, according to a new study. Being female, having higher body mass index (BMI), obstructive sleep apnea, osteoarthritis, depression, low back pain and alcohol abuse was associated with greater likelihood of using these medications. However, being over the age of 65, Hispanic race/ethnicity and required copayments was associated with lower odds of their use....

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New Drug Has Potential to Treat Neonatal Seizures  Voir?

Gluconate present in fruit and honey found to act like an anticonvulsant controlling seizures by targeting chloride channel activity in neonatal neurons of rodent models. This could open up new avenue for treating epilepsy in human newborns. This study led by Penn State researchers was published in the journal iMolecular Brain/i. "Neonates are the most vulnerable population to seizures but there is still no effective medication for the treatment of neonatal epilepsy," said Gong Chen, professor of biology and the Verne M....

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Policies of Few Asian Nations on Illicit Drug Use Found to be Changing  Voir?

Stringent policies originally adopted by Asian nations to curb illicit drug use are beginning to modify, with some nations seeking alternatives while others are taking more strict line against drugs, according to a new RAND Corporation report. Thailand is on the forefront of Southeast Asian nations that are reconsidering longstanding policies, moving to adopt greater harm reduction, approving the use of medical cannabis and easing restrictions on the traditional use of the substance kratom. ...

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New Drug Discovery Approach Could Help Develop Personalized Neuropsychiatric Treatments  Voir?

bHighlights:/b ul class="group-list punch-points"li A novel technique has been developed that can be used for screening potential new psychiatric drugs/lili Human blood cells are used for screening the new drug molecules /liliThis could lead to the development of personalized therapies for neuropsychiatric disorders /li/ul New approach to drug discovery developed by scientists at the University of Cambridge, UK, could lead to personalized medicines for treating neuropsychiatric ...

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HIV Prevention Drug can Curb the Epidemic for High-risk Groups in India: Study  Voir?

In India, pre-exposure prophylaxis (PrEP), a combination drug used to prevent HIV infection would be a cost-effective way to reduce the spread of HIV and increase survival, stated a new study published in Clinical Infectious Diseases. "We know PrEP helps stop the spread of infection; the question is whether it is a good use of limited resources? Our study shows that PrEP is a cost-effective strategy for both MSM and PWID in India. For these groups, especially in areas with high HIV incidence, ...

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Link Between Bulling and Pain Medication Use Discovered  Voir?

Among bullied students, the use of pain medications was significantly higher even when controlling for the amount of pain they felt, as well as age, gender, and socioeconomic status, stated a school-based survey study of all students in grades 6, 8, and 10 in Iceland. The findings are published in Acta Paediatrica.A total of 10,390 students completed anonymous surveys and answered questions about bullying, pain, and pain medication use. "Interventions aimed at reducing bullying and promoting ...

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New Drugs for Improving Metabolic Health Identified  Voir?

New drugs which blocks enzyme involved in protein digestion could improve metabolic health, according to a new study published ahead of print in the iAmerican Journal of Physiology--Gastrointestinal and Liver Physiology/i. The paper was chosen as an iAPSselect/i article for May. Trypsin--an enzyme that bonds to proteins--is the primary enzyme responsible for digesting protein in the digestive tract. Drugs (called serine protease inhibitors) that prevent enzymes such as trypsin from working ...

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Promising Results of a New Drug for Severe Dry Eye Disease  Voir?

Novel enzyme-based eye drops found to reduce signs and discomfort of severe dry eye disease among participants of phase I/II clinical trial, according to a paper in iTranslational Vision Science and Technology/i. The trial compared eye drops containing a biosynthetic form of an enzyme called DNase with eye drops without the enzyme. DNase breaks up nucleic acid-based material on the surface of the eye. "Participants in the trial who used the drops with DNase reported less eye discomfort and their corneas were healthier," said Dr....

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Drug Candidate for Reversing Mucosal Barrier Damage by HIV Tested  Voir?

Research in preclinical models suggests that recombinant molecule could act as a topical anti-HIV microbicide. A vaginal microbicide that could prevent sexual transmission of HIV-1 in women has tremendous potential for saving lives and helping staunch an epidemic. But the delicate milieu of microbes that naturally colonize the vagina and maintain a healthy mucosal barrier have made the search for such a microbicide challenging, thwarting clinical trials of the most promising candidates. Investigators ...

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New Smart Pill Bottle That Keeps Drugs Safe Developed  Voir?

Researchers used a new sensor technology to create a smart pill bottle that sends wireless alerts when it detects tampering, overdose or unsafe storage conditions. Digital technology offers opportunities to improve traditional approaches to issues threatening human health. For example, networks of tiny wearable sensors deployed in hospitals can be used to track influenza outbreaks in real time. But the high costs associated with electronic manufacturing means that these sensors aren't available ...

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Drug for Rheumatoid Arthritis to Decrease Zika Birth Defects in Mice  Voir?

Immunosuppressive drug used for arthritis could reduce the rate of fetal deaths and congenital defects in the Zika virus-infected pregnant mice's offspring, according to the researchers of the Johns Hopkins Medicine. The U.S. Food and Drug Administration-approved medicine, anakinra, once commonly used to treat rheumatoid arthritis and other autoimmune diseases in newborns and adults, has largely been replaced by more effective drugs. However, in the Zika-infected mouse experiments, the drug ...

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New Drug Found Safe and Effective for Huntington Disease  Voir?

New drug for Huntington disease is found to be safe and effective in lowering the levels of abnormal protein, according to the results of an international clinical trial. In a study published in the iNew England Journal of Medicine/i, researchers from UBC and their colleagues have demonstrated for the first time that the drug, IONIS-HTTRX (now known as RO7234292) successfully lowered levels of the mutant huntingtin protein--the toxic protein that causes Huntington disease--in the central nervous system of patients....

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Delayed Diagnosis of Prostate Cancer Among Men Who Take Drugs for Enlarged Prostate  Voir?

Men taking drug treatment for benign prostatic hyperplasia (BPH) experienced a delay in diagnosis of their prostate cancer and were twice as likely to have advanced disease at the time of diagnosis, according to the researchers of the University of California San Diego School of Medicine. Men who took drugs that inhibit the enzyme 5 (and) #945;-reductase, known as 5-ARIs, were diagnosed with prostate cancer 3.6 years after the first signs of elevated levels of a protein called prostate-specific antigen (PSA) compared to 1....

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Relaunch of New Index That Tracks Impact of Pharmaceuticals Worldwide  Voir?

New index that tracks more diseases across many countries is going to be re-launched by the faculty at Binghamton University, State University of New York who previously launched the Global Health Impact Index. A re-launch event, "The Global Health Impact Project: Progress Towards the Sustainable Development Goals," will takes in the Robertston Hall at the Liechtenstein Institute of Self-Determination at Princeton University. A new website and models will be introduced, and two roundtable discussions will follow....

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New Drug Reduces Relapse Risk With Neuromyelitis Optica  Voir?

In neuromyelitis optica spectrum disorder (NMOSD) condition, the drug eculizumab, a synthetic antibody inhibits the inflammatory response, significantly reducing the risk of relapse. NMSOD is a rare but severe autoimmune inflammatory disorder and can cause blindness, paralysis and death. Mayo Clinic researchers and international collaborators report their findings in a randomized, double blind, placebo-controlled study published in the New England Journal of Medicine. Their work also will ...

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Treatment-resistant Gonorrhea: Antibiotic Drug Combination Proves Effective  Voir?

For treating genital gonorrhea, antibiotic gentamicin with azithromycin worked almost as well as the currently used ceftriaxone, revealed research team from University Hospitals Birmingham. Scientists comparing treatments for gonorrhoea have identified a drug combination that could be an effective back-up for patients not responding to current therapy. The study, funded by the National Institute for Health Research (NIHR), published in The Lancet and is the first randomised controlled trial ...

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Investigational Drug Has Potential to Treat Genetic Form of ALS  Voir?

New experimental drug slowed down the progression of amyotrophic lateral sclerosis (ALS) in people having superoxide dismutase 1 (SOD1) gene mutations. An early stage trial indicates that people could tolerate this experimental drug well. The preliminary study will be presented at the American Academy of Neurology's 71st Annual Meeting in Philadelphia. ALS is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. People with ALS lose the ability to ...

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Erectile Dysfunction Drug Effective as Heart Failure Treatment  Voir?

In sheep, tadalafil, an erectile dysfunction drug was found to slow or even reverse the progression of heart failure, stated University of Manchester scientists. The British Heart Foundation funded study is a breakthrough in the treatment for the disease in which five year survival rates are lower than most common cancers. The study of Tadalafil - which is in the same class as Viagra - proves that the drug is biologically effective as a treatment for heart failure in sheep. However, lead author ...

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Cannabis-based Drug as Epilepsy Treatment  Voir?

For children with difficult-to-treat epilepsy Dravet syndrome, taking a pharmaceutical formulation of cannabidiol, a cannabis-based drug cuts seizures nearly in half, stated a phase 3 study released today that will be presented at the American Academy of Neurology's 71st Annual Meeting in Philadelphia, May 4 to 10, 2019. Dravet syndrome, which starts in infancy, can lead to intellectual disability and frequent, prolonged seizures. Cannabidiol is derived from marijuana that does not include the psychoactive ...

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Drug Combination to Treat Type 2 Diabetes in Children  Voir?

Liraglutide, in combination with metformin, had sound effect in treating children with type 2 diabetes in the Ellipse trial, according to Jane Lynch, M.D., FAAP, professor of pediatrics at UT Health San Antonio. Results of this study were announced at the Pediatric Academic Societies 2019 meeting in Baltimore, Md and published in iThe New England Journal of Medicine/i. Currently only two drugs, metformin and insulin, are approved by the U.S. Food and Drug Administration for the treatment of Type 2 diabetes in children....

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New Method Could Help Produce Pure (and) Safe Drugs  Voir?

New method which could speed up the drug discovery process and produce high quality safe and pure drugs, was invented by Physics and Chemistry scholars from Hong Kong Baptist university (HKBU) through a specific nanomaterial layer to detect the target molecules in pharmaceuticals and pesticides in five minutes. The new HKBU invention can be applied to the drug discovery process, as well as the production and quality control stages of pharmaceutical manufacturing. It can also be used in environmental monitoring....

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Drug Combo Found Effective Against Another Leukemia  Voir?

Arsenic-based drug combination found useful for treating second form of leukemia, revealed by a team of scientists led by Pier Paolo Pandolfi, MD, PhD, Director of the Cancer Center and Cancer Research Institute at Beth Israel Deaconess Medical Center, published in iCell Research/i. Every year, nearly 11,000 Americans die of AML, a blood cancer that affects mainly older adults. While most patients initially respond to chemotherapy, more than half of those who respond will eventually relapse ...

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Drugs Show Promise in Treating Stroke, Dementia  Voir?

Two drugs commonly used to treat heart disease and angina show promise in preventing stroke and dementia, finds a new study. The findings of the study are published in the journal iEClinicalMedicine/i. Treatments that prevent recurrence of types of stroke and dementia caused by damage to small blood vessels in the brain have moved a step closer, following a small study. The drugs - called bcilostazol/b and bisosorbide mononitrate /b- are already used to treat other conditions, such as heart disease and angina....

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Cook Your Wash: An Effective HIV Prevention Technique Among Injection Drug Users  Voir?

HIV can be spread through sharing of equipment used to prepare drugs even without sharing injections. However, a simple intervention such as heating the equipment with a cigarette lighter for 10 seconds can eliminate the HIV virus, preventing the transmission. The findings of the study are published in the iJournal of Acquired Immune Deficiency Syndrome/i. The findings used to inform a public health campaign called 'Cook Your Wash,' have helped reduce rates of HIV transmission in London, Ontario....

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Drug for Muscle Wasting Helps Children With Later-onset Disease  Voir?

Drug that is effective in treating spinal muscular atrophy (SMA), the rare muscle-wasting disease, early in life could be associated with an improvement in older children, according to a study published in iNeurology/i, the medical journal of the American Academy of Neurology. Spinal muscular atrophy is a neurodegenerative disease that attacks nerve cells in the spinal cord, leading to muscle weakness. This can affect breathing, swallowing, walking and head control. There are several types of SMA, some of them fatal....

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Drugs Alters Genes in Breast Tumors to Block Resistance  Voir?

Breast cancer treatment using two cancer drugs could prevent endocrine resistance by killing the tumor cells through two different gene pathways, according to scientists of the University of Illinois. The two drugs used in the study, selinexor and 4-OHT, caused the cancer cells to die and tumors to regress for prolonged periods, said food science and human nutrition professor Zeynep Madak-Erdogan, the principal investigator on the study. The study, published in the journal iCancers/i, ...

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CRISPR Gene-editing Technology Combines With Cancer Drug Discovery  Voir?

With CRISPR gene-editing technology, new paper published in Nature Chemical Biology, Harvard University Assistant Professor of Chemistry and Chemical Biology Brian Liau has revealed why certain amyloid myeloid leukemia drugs only work some of the time. 11,000 people are predicted to die from acute myeloid leukemia (AML) in 2019, according to the American Cancer Society. The cancer starts in the bone marrow. There, mutated genes fail to prevent blood cells from replicating again and again and again, growing tumors....

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On-chip Drug Screening Identifies Antibiotic Resistance  Voir?

A new microfluidic-based drug screening chip developed by a KAIST research team was found to identify synergistic interactions between two antibiotics in eight hours. This chip can be a cell-based drug screening platform for exploring critical pharmacological patterns of antibiotic interactions, along with potential applications in screening other cell-type agents and guidance for clinical therapies. Antibiotic susceptibility testing, which determines types and doses of antibiotics that can ...

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New Medicines for Obesity Basing on Genetic Variants  Voir?

Around four million people in the UK have got genetic variants which protect them from obesity, type 2 diabetes and heart disease, discovered by the team of researchers of the University of Cambridge, which could lead to the development of novel drugs that aids in losing weight. Scientists have known for several years that genes can influence a person's weight. One of the genes that is known to play a key role in regulating weight is MC4R, which codes for the melanocortin 4 receptor. This receptor ...

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Cannabidiol Aids to Deliver Medications into the Brain  Voir?

Cannabidiol (CBD) could aid to deliver medications to the mouse brain bypassing blood-brain barrier (BBB), according to new study published in the ACS journal iMolecular Pharmaceutics/i. CBD is a non-psychoactive compound in cannabis, being touted as beneficial for many health conditions, ranging from anxiety to epilepsy. Although much more research is needed to verify these claims, scientists have now shown that CBD could have a different use as a "Trojan horse": helping slip medications across the BBB....

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Hypertension Drug to Treat Parkinson's and Dementia  Voir?

Drug prescribed to treat high blood pressure could also aid to treat Parkinson's, Huntington's and other forms of dementia in studies carried out in mice and zebrafish at the University of Cambridge. A common feature of these diseases - collectively known as neurodegenerative diseases - is the build-up of misfolded proteins. These proteins, such as huntingtin in Huntington's disease and tau in some dementias, form 'aggregates' that can cause irreversible damage to nerve cells in the brain. In ...

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Leucine-rich Diet may Fuel Breast Cancer's Drug Resistance  Voir?

Relationship between the amino acid leucine and tamoxifen resistance has been identified by scientists at the Cancer Center at Beth Israel Deaconess Medical Center (BIDMC). About one in eight women in the United States will develop breast cancer in her lifetime. The vast majority of these cancers rely on the hormone estrogen to grow. Estrogen-receptor positive (ER+) breast cancer tumors are frequently treated with the drug tamoxifen, which blocks the hormone's effect on the tumor. However, ...

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"Reverse Engineered" Brain Cancer Cells Useful for Identifying New Drug Targets  Voir?

bHighlights:/b ul class="group-list punch-points"li'Reverse engineering' of brain cancer cells is now possible using the latest technology/liliThis will help in the identification of new drug targets for dangerous cancers such as glioblastoma/liliThis will facilitate the development of novel treatments for glioblastoma/li/ul 'Reversing engineering' of brain cancer cells derived from glioblastoma has now been made possible by using the latest high-tech ...

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Mindful Body Awareness Training Can Help Women Recover from Drug Addiction  Voir?

Mindful body awareness training during treatment for drug addiction can prevent relapse, reports a new study. The findings of the study are published in the journal iDrug and Alcohol Dependence/i. A novel type of body awareness training helps women recover from drug addiction, according to new research from the University of Washington. People in the study made a marked improvement, and many improvements lasted for a year. It's the first time the mindfulness approach has been studied in ...

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Mass Drug Administrations to Protect Against Malaria  Voir?

Mass drug administration(MDA) can provide community-level protection against iPlasmodium falciparum/i malaria, according to a new study published in ieLife/i, suggesting that malaria elimination programs intending to use MDA as part of their efforts should approach communities in a way that fosters high levels of buy in and participation. The global burden of malaria has decreased over the last decade and many nations are aiming to eliminate the disease altogether, but a major challenge ...

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Diabetes Drug to Lessen the Risk of Heart Disease in Non-diabetics  Voir?

Common diabetes drug metformin could alter the harmful thickening of heart muscle that leads to cardiovascular disease, according to a study done by the team of researchers from the University of Dundee. Scientists led by Professor Chim Lang, Head of the Division of Molecular and Clinical Medicine at Dundee, discovered that metformin has the potential to be repurposed as a heart disease treatment in non-diabetic patients. The MET-REMODEL Trial, published in the prestigious iEuropean Heart ...

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Antidiabetic Drug Shown to Protect Against Kidney Failure  Voir?

bHighlights/b: ul class="group-list punch-points"liCanagliflozin, a drug developed to lower glucose levels in diabetics has been found to protect against kidney failure, one of the major complications of diabetes requiring regular dialysis and possibly a kidney transplant/liliThe drug can also significantly reduce the incidence of cardiac complications such as heart attack, stroke and premature death/liliDiabetes affects nearly 350 million ...

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Drug to Lower The Risk of Kidney Failure in Type 2 Diabetes  Voir?

Canagliflozin decreases the risk of kidney failure by one-third in patients with type 2 diabetes and kidney disease, according to a new clinical trial. "For the first time in 18 years, we have a therapy for patients with Type 2 diabetes and chronic kidney disease that decreases kidney failure," said Kenneth Mahaffey, MD, professor of medicine at the Stanford University School of Medicine and co-principal investigator of the trial. "Now, patients with diabetes have a promising option to guard ...

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Medicines Used for Enlarged Prostate Raises Type 2 Diabetes Risk  Voir?

Men with enlarged prostates should continue to take commonly prescribed drugs called 5-alpha-reductase inhibitors, but with additional health monitoring, according to the research team led by the University of Edinburgh and UCL. 5-alpha-reductase inhibitors reduce the production of hormones called androgens and help to treat symptoms such as reduced urinary flow. Previous short-term studies had suggested these drugs, which include finasteride and dutasteride, might affect metabolism and ...

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One-third of People With Cancer Use Complementary and Alternative Medicine  Voir?

One-third of cancer patients found to use complementary and alternative medicines like meditation, yoga, acupuncture, herbal medicine, and supplements, according to Dr. Nina Sanford of the UT Southwestern Medical Center. She made the discovery drawing renewed attention to habits she said cancer patients must disclose during treatment. Dr. Sanford is an Assistant Professor of Radiation Oncology who specializes in and treats cancers of the gastrointestinal tract. Herbal supplements were the ...

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Antibiotics in Over-the-counter Throat Medications Enhances Resistance  Voir?

Inappropriate usage of antibiotics that are available legally in over-the-counter (OTC) throat medications could lead to the development of antibiotic resistance which is against the World Health Organisation (WHO) goals, according to new research presented at European Congress of Clinical Microbiology (and) Infectious Diseases (ECCMID) in Amsterdam, Netherlands. Certain OTC products aimed at treating sore throats contain topical antibiotics, and medications of this type are widely available around ...

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ESMO to Deal With The Deficiencies of Essential Medicines  Voir?

Deficit of essential medicines used for cancer could have an impact on patient care throughout Europe. ESMO(European Society For Medical Oncology)-the leading European professional organisation along with the European Parliament organised a cross-partisan event entitled "Shortages of Inexpensive, Essential Medicines: Calling for Tangible Political Commitments in the EU" to make sure that this issue remains a top priority on the EU policy agenda. Shortage of inexpensive essential medicines have complex and multifactorial causes....

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Hepatitis C To Be Prevented By Decreasing Transmission Among People Who Inject Drugs  Voir?

Augmenting efforts to avoid transmission of hepatitis C among people who inject drugs, could decrease all subsequent infections by 43 per cent worldwide, according to a study done by the team of researchers at the University of Bristol published in the iLancet Gastroenterology and Hepatology/i. Hepatitis C is a virus that is passed on through blood exposure and results in liver disease. It is estimated that over 70 million people are infected with the hepatitis C virus worldwide and that ...

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Anti-Inflammatory Drug Found Effective in Treating Depression  Voir?

Medicine which inhibits inflammation like arthritis can also provide beneficial effect in treating patients with depression, according to the new meta-analysis. The World Health Organization (WHO) calls depression one of the most serious mental disorders, and researchers around the world are trying to improve treatment of the disease. "Our study shows that a combination of anti-inflammatory medicine, which is what arthritis medicine is, and antidepressants can have an additional beneficial effect on patients with a depression....

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New Discovery Aids to Alleviate Side Effects of Erectile Dysfunction Drugs  Voir?

Full-length structure of the rod photoreceptor phosphodiesterase 6 (PDE6), an enzyme that plays an essential role in human vision, using single-particle cryo-electron microscopy, was identified by researchers from the University of California, Irvine. Their study was published in iScience Advances/i magazine. PDEs are associated with various diseases and are targets of several widely used drugs and major targets for drug development. Unfortunately, many of these enzymes have similar structures, ...

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Investigational Drug Has Potential to Treat Opioid Withdrawal Symptoms  Voir?

Rapastinel, a new experimental drug initially developed as an antidepressant, later found to reverse the sudden, severe signs of opioid withdrawal in rats in just three days. This drug offers a better solution for opioid withdrawal compared to the available common medicines which cause side effects and relapses before treatment completion. The findings suggest rapastinel could be useful to help manage withdrawal during the critical first days after someone has entered treatment and is trying ...

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Mass Drug Administration Decreases Scabies by 90% in Solomon Islands  Voir?

Mass drug administration (MDA) using two antibiotics ivermectin and azithromycin, could reduce scabies cases and bacterial infection impetigo to a large extent, according to new research published in iLancet Infectious Diseases/i. The study was conducted by the London School of Hygiene (and) Tropical Medicine (LSHTM), Murdoch Children's Research Institute (MCRI), the Kirby Institute at UNSW Sydney and the Solomon Islands Ministry of Health and Medical Services. It saw the entire population ...

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Psychedelic Drug MDMA Reopens 'Critical Period' Which Aids to Treat Stress Disorder  Voir?

Psychedelic drug MDMA reawakens a window, called "critical period," when the brain is sensitive to learning the reward value of social behaviors which explains, how it could help in treating patients with post-traumatic stress disorder (PTSD), according to the findings of Johns Hopkins neuroscientists, published in iNature/i. Critical periods were first described in the 1930s in snow geese. About 24 hours after a gosling hatches, if mother goose is nowhere to be found, the hatchling will bond with an object, including non-living ones....

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Dernière mise à jour : 19/05/2019 @ 10:31

 
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