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Latest Drug Toxicity News

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Anti-stroke Drug Proves Safe for Patients  Voir?

Anti-stroke drug 3K3A-APC invented by The Scripps Research Institute (TSRI) showed promising results in patients with acute ischemic stroke. It also substantially reduced the incidence of hemorrhage in patients. "These results lay the groundwork for the next steps toward FDA approval," says John Griffin, PhD, professor at TSRI, whose team invented 3K3A-APC. Stroke is the fifth leading cause of death in the United States and the number one cause of adult disability. Acute ischemic strokes occur when a clot blocks blood flow to the brain....

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Mixing Gabapentin With Other Drugs can Have Serious Side Effects  Voir?

Gabapentin, a non-opioid painkiller is increasingly being misused by abusers by mixing the drug with opioids, marijuana, cocaine and opioid treatment medication. This can have serious side effects on the central nervous system which include euphoria and sedation. Gabapentin, a nerve pain medication and anticonvulsant sold under the brand name Neurontin and others, increasingly is being misused, necessitating prescribers to understand its abuse potential and risk profile, said Rachel Vickers Smith, Ph....

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Can Transgender Women Rely on Medicine Alone to Lower Testosterone Levels?  Voir?

Majority of transgender women are unable to reliably lower their testosterone levels into the typical female physiologic range with medicine alone. In a first study of its kind, a research team investigates the efficacy of transgender treatment in its stability to maintain low testosterone levels over a prolonged period of several years. The study is published in the journal iEndocrine Practice/i. Transgender individuals are those with gender identity different from external sexual anatomy at birth....

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New Algorithm That Uncovers Cellular Dynamics can Guide the Designing of New Drugs  Voir?

A new machine learning algorithm helps understand the mysterious interactions that occur inside cells. The SWING (Sliding Window Inference for Network Generation) algorithm uses time-series data to reveal the underlying structure of cellular networks and helps connect the dots among the genes' interactions inside cellular networks. Biologists have long understood the various parts within the cell. But how these parts interact with and respond to each other is largely unknown. "We want to understand ...

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Placenta-on-a-chip to Test Drug Transfer Across the Human Placental Barrier  Voir?

Feasibility of "organ-on-a-chip" platform in studying how drugs are transported across the human placental barrier has been demonstrated by researchers at the University of Pennsylvania's School of Engineering and Applied Science. Some maternally-administered medications can enter the fetal bloodstream, but how the placenta determines which molecules can get through is still poorly understood. The ways of testing this process are limited. Animal models don't capture important details of human ...

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Tiny Kidneys for Drug Testing Using Stem Cell-like Green Cells  Voir?

Stem cell scientists generate more human-like tiny kidneys for testing new drugs and creating renal replacement therapies. "Stem-cell-based technologies hold great promise for developing kidney replacement and regeneration therapies," said Nils Lindstrom, first author of three new studies and a research associate in Stem Cell Biology and Regenerative Medicine at the Keck School of Medicine of USC. "Getting there requires detailed knowledge of how kidneys normally form so the process can be replicated in cell cultures in the lab....

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Ustekinumab Psoriasis Drug can Also Treat Heart Inflammation  Voir?

bHighlights/b ul class=group-list punch-points liUstekinumab also sold under the name Stelara can treat aortic inflammation, a key marker of future risk of major cardiovascular events./li liUstekinumab is a drug known to treat the psoriasis which is nothing but chronic infammatory disease./li liNinteen percent of patients who took the drug saw a decrease in their aortic inflammation./li/ul Ustekinumab, an antibody usually used to treat psoriasis can now decrease aortic inflammation finds a new study....

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Namocare to Turn India Into the Largest Pharma Manufacturer in the World  Voir?

'Namocare' Indian central government's national health insurance scheme may make India the largest drug maker in the world, says Union Chemicals and Fertilisers Minister, Ananth Kumar. Inaugurating the third edition of the 'India Pharma 2018 and India Medical Device 2018, International conference and exhibition' here, Ananth Kumar said a new pharmaceuticals policy in the offing would ensure effective implementation of 'Namocare', which has the potential to turn India into the largest pharma manufacturer of the world in the next three years....

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New Drug may Help Infants With Genetic Disorder Gain Motor Function  Voir?

bHighlights/b ul class="group-list punch-points" liNusinersen, a new drug may help infants with spinal muscular atrophy (SMA) regain vital motor function./li liSMA Type 1 occur in infants with disease specific genetic mutation and usually results in progressive muscle weakness./li liNusinersen showed that infants gain in motor function and also survive without any additional support./li/ul The new drug Nusinersen may have a positive impact on the lives of infants with ...

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Existing Blood Pressure Medication may Prevent Type 1 Diabetes  Voir?

bHighlights/b ul class=group-list punch-points liMethyldopa, which is commonly used to control high blood pressure may also prevent type 1 diabetes development./li liSixty percent of people at risk of getting type 1 diabetes possess the DQ8 molecule which significantly increases the chances of getting the disease./li liMethyldopa can block this DQ8 molecule and block the onset of thetype 1 diabetes./li/ul Methyldopa, a high blood pressure medication for pregnant women, ...

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Cystic Fibrosis Patients With Specific Mutations To Benefit From New Drug  Voir?

bHighlights:/bul class="group-list punch-points"liDual drug combination of tezacaftor/ivacaftor has been approved by the FDA for cystic fibrosis (CF) /liliCystic fibrosis is a genetic disorder where the cystic fibrosis transmembrane conductance regulator (CFTR) protein function is abnormal due to mutations in the gene that codes for it/liliCombination drug that can correct the function of the CFTR protein has been approved to treat people ...

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Asthma Medications may Influence Women's Ability to Conceive  Voir?

Long-acting steroid inhalers when used on a regular basis, resulted in young asthmatic women conceiving quickly as normal healthy women finds a new study. The findings of this study are published in the IEuropean Respiratory Journal/I. However, the study of more than 5,000 women in Australia, New Zealand, the United Kingdom and Ireland also shows that women with asthma who use long-acting asthma preventers conceive as quickly as other women. The research was led by pharmacist and research fellow, Dr....

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Drug Resistance to Lung Cancer Can Now Be Detected  Voir?

Molecular simulations can help understand the mechanism behind drug resistance to lung cancer medications. Scientists from the Universities of Bristol and Parma, Italy, have used molecular simulations to understand the resistance to osimertinib - an anticancer drug used to treat types of lung cancer. bOsimertinib For Lung Cancer/b Osimertinib binds tightly to a protein, epidermal growth factor receptor (EGFR), which is overexpressed in many tumors. EGFR is involved in a pathway that ...

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Novel Method to Produce Innovative Drugs Developed  Voir?

A new cost-effective method synthetically producing a biorenewable platform chemical called triacetic acid lactone (TAL) has been developed by a team of chemical engineers at the University of Texas at Austin. The new method could be used to produce innovative new drugs and sustainable plastics at an industrial scale. The findings of the study are published in Proceedings of the National Academy of Sciences. Led by Hal Alper, professor in the McKetta Department of Chemical Engineering in the ...

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Epilepsy Drug Levetiracetam may be Better Than Phenobarbital  Voir?

bHighlights:/b ul class = "group-list punch-points" liLevetiracetam and Phenobarbital are the two most commonly prescribed drugs for infantile epilepsy./li liLevetiracetam may be more effective than Phenobarbital./li liThese findings provide novel evidence to favor levetiracetam instead of phenobarbital for initial monotherapy of infantile nonsyndromic epilepsy./li/ul bLevetiracetam over Phenobarbital for infantile epilepsy/b Levetiracetam, the most commonly prescribed drug for U....

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Injecting Nanocarriers may Release Drugs in The Body for Months  Voir?

bHighlights:/b ul class = "group-list punch-points" liNanocarriers that can deliver and release drugs into the body for months have been developed./li liThis drug delivery act as a drug depot inside the body./li liIt then slowly breaks down into spherical nanomaterials to provide continuous release of drugs for months./li/ul A nanocarrier formulation that forms into a gel inside the body at the site of injection and then continuously releases drugs through nanoscale drug-loaded ...

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Drug Research for Eye Disease Finds Potential Cancer Drug  Voir?

bA neutron analysis that studies drugs that are clinically used to treat glaucoma finds drugs that may act against an enzyme linked to cancer/b. A research team led by the Department of Energy's Oak Ridge National Laboratory used neutron macromolecular crystallography to investigate the different states of three glaucoma drugs as they interact with the targeted enzyme, human carbonic anhydrase II (hCA II). "Our goal was to observe differences in the presentation of three clinically used glaucoma ...

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Commonly Prescribed Drug Effectively Treats Infants with Epilepsy  Voir?

Most commonly prescribed drug levetiracetam is found to be more effective than phenobarbital to treat infants with nonsyndromic epilepsy, finds a research team. 40 percent of infants who received levetiracetam for six months did not require a second anti-epileptic drug to control their seizures and became seizure-free within three months of starting treatment. However, only 16 percent of infants who received phenobarbital achieved the same outcome. The findings of the study are published in the journal iJAMA Pediatrics....

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Placebo Pills Help Fight Cancer-related Fatigue  Voir?

Power of placebo pills, even when fully disclosed to cancer patients might be harnessed to reduce fatigue in cancer survivors, revealed study conducted by University of Alabama at Birmingham and Harvard School of Medicine researchers. For cancer survivors, few treatments are available to alleviate fatigue after treatment, and the most effective pharmacological interventions come with side-effect warnings that include panic, psychosis and heart failure. In a study published in Nature Scientific ...

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Haryana: First AMRIT Pharmacy Inaugurated  Voir?

Union Health Minister J.P Nadda inaugurated Haryana's first AMRIT pharmacy aiming to strengthen generic medicine availability. The inauguration was part of national deworming initiative launched by the Union Health Ministry against intestinal worms infections in children, with Nadda saying the government aims to cover 32 crore children as part of the scheme. National Deworming Day was launched in 2015 which was implemented in 11 States/Union Territories across all Government and Government-aided ...

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US Death Rates from Alcohol Abuse, Drugs and Suicides, on the Rise  Voir?

Drug abuse, alcohol abuse and suicides are contributing to an alarming drop in US life expectancy, shows study. Middle-aged white Americans and rural communities are particularly affected, warn experts. The study is published in iThe BMJ today/i. Steven Woolf at Virginia Commonwealth University and Laudan Aron at the Urban Institute in Washington DC, argue that the ideal of the "American Dream" is increasingly out of reach as social mobility declines, and fewer children face a better future than their parents....

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New Way to Make Drug Testing More Efficient Devised  Voir?

New device created by McMaster University engineers could make drug testing more affordable and to speed up the discovery of new drugs. In addition, to help address the surge of antibiotic resistance, the technology can also help to more quickly identify "helper drugs" that can make even drug-resistant bacteria susceptible to our current antibiotics. Chemical Engineering Associate Professor Todd Hoare and Rabia Mateen, a PhD candidate in Biomedical Engineering have devised printed paper-based ...

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Micro-technology That Measures Cells May Help Develop New Drugs  Voir?

bA micro-technology tool that can measure cells hundred times faster than current technologies has been developed/b by a research team at University of California, Los Angeles (UCLA) and Rutgers University. The new tool could help in the discovery of medications for wide range of diseases related to abnormal use of force by cells. bThe new device could make it easier and faster to test and evaluate new drugs for diseases associated with abnormal levels of cell strength, including hypertension, asthma and muscular dystrophy/b....

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New Tool Matches Cancer Drug to Genetic Anomaly  Voir?

A new system that rapidly determines which cancer drugs are likely to work best for a patient according to his genetic markers was developed by research teams from the University of Delaware and Georgetown University. The first publicly available system of its kind, their database, eGARD (extracting Genomic Anomalies association with Response to Drugs), is described in iPLOS One/i. When your genes work correctly, they function like miniature factory plant managers, directing the production of life-sustaining proteins....

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Drug Dosing For Kids Needs To Be More Precise  Voir?

Children should not be considered 'small adults' when it comes to prescribing medications, but it can be difficult to determine the right dosage of a particular drug for young patients. A newIBritish Journal of Clinical Pharmacology/Iarticle analyzed drug dosage guidelines and found that bguidelines given for pediatric doses are usually based on simple formulas (such as mg/kg), available dosing formulations, and prior patterns of use/b. The analysis also found that it is common to ...

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Nanotechnology may Beat Drug Resistance in Cancer Treatment  Voir?

bOncologists may be able to disable drug-resistance in cancer therapy for at least five days to create a therapeutic window for chemotherapy/b. A research team at the University of Maryland finds a technique that uses specially designed nanoparticles and near-infrared laser treatment to cause cancer cells to lose their multidrug resistance capabilities for days at a time. bThis creates a therapeutic window for chemotherapy to combat even the most drug-resistant cells left behind after surgery or earlier treatment/b....

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Oracle's New Cloud-based eClinical Solution to Ease Drug Development  Voir?

The launch of a new holistic, unified cloud-based eClinical solution by Oracle is intended to bring new drugs to the market in a timely manner, while maintaining quality and safety. The new "Clinical One Platform" will unify clinical development operations and information in a single environment with shared functions and an easy-to-use interface for sites, clinical coordinators and their counterparts. The holistic, unified cloud solution, is being built from the ground to address the needs ...

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Novel Drug can Reverse Brain Deficits caused by Alcohol  Voir?

A new drug identified can help reboot the brain and reverse the damaging effects caused by heavy alcohol consumption. Queensland University of Technology (QUT) researchers conducted their studies in adult mice show that two weeks of daily treatment with the drug tandospirone reversed the effects of 15 weeks of binge-like alcohol consumption on neurogenesis - the ability of the brain to grow and replace neurons (brain cells). The findings have been published in iScientific Reports./iul ...

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Asthma Patients Could Find Relief with New Drug Therapy  Voir?

bHighlights:/b ul class="group-list punch-points" liScientists identify a compound that relaxes airway smooth muscle cells to treat asthma/li liThe drug called TSG12 has been developed from a protein called metallothionein-2 or MT-2 that relaxes smooth muscle cells in asthmatic lung tissue/li liTSG12 is non-toxic and more-effective than bronchodilators currently used to treat asthma /li/ul bEffective treatment in a protein form can help millions of individuals with ...

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Muscular Dystrophy Givinostat Drug can Help Treat Heart Failure  Voir?

ul class="group-list punch-points" liGivinostat, new muscular dystrophy drug can help treat heart failure with preserved ejection fraction (HFpEF)./li liHFpEF occurs due to defective heart relaxation /li liAfter drug intake, cardiac relaxation without altering blood pressure was observed /li/ul Givinostat, a new drug used for muscular dystrophy can help the heart relax properly as in case of diastolic dysfunction (heart relaxation abnormality), the heart is unable to relax....

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Fighting Hepatitis B Virus With a New Experimental Drug  Voir?

The change in structure of the hepatitis B virus when bound to an experimental drug is a step forward in the design of drugs that fight the hepatitis B virus, shows a research team from Indiana University. It's estimated that 2 billion people worldwide have had a hepatitis B virus infection in their lifetime, with about 250 million -- including 2 million Americans -- living with chronic infection. Although a vaccine exists, there is no cure. The study, published in the journal ieLife/i, ...

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Symptoms of Alcoholism Make It Difficult to Take the Drug That Treats Alcoholism  Voir?

Symptoms of alcoholism make it difficult for some people to regularly take the drug naltrexone, which could help treat their disease, according to a new study by Oregon State. The findings are published in the iAnnals of Behavioral Medicine/i. The finding helps researchers better understand how to intervene with patients to improve the effectiveness of the medication, said Sarah Dermody, an assistant professor in the School of Psychological Science in OSU's College of Liberal Arts. "The ...

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Common Dye Proves to be an Effective Antimalarial Drug  Voir?

bHighlights/b ul class="group-list punch-points" liMethylene blue dye could be a safe antimalarial that destroys malarial parasites at an incredible rate./li liWithin two days infected patients were cured of the disease and were no longer able to transmit the disease, even if they were bitten by new mosquito./li liMethylene blue dye is said to work well in species that are resistant to certain anti-malarial medicines./li/ul Methylene blue dye may destroy malarial parasite and that too in 48 hours finds a new study....

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Catheter Ablation Can Replace Pills For Atrial Fibrillation Therapy  Voir?

Patients with atrial fibrillation or irregular heart rhythm on radiofrequency catheter ablation compared to traditional drug therapies have significantly lower hospitalization and mortality rates. Millions of people around the world are diagnosed with heart failure and atrial fibrillation every year. In the weakened state, the heart is unable to pump enough oxygenated blood throughout the body. "Atrial fibrillation prevents the heart from filling and pumping properly," beginsNassir F. Marrouche, M....

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Ibrutinib Drug may Target a New Receptor Protein to Treat Cancer  Voir?

bHighlights/b ul class= (and) #23364;roup-list punch-points (and) #65533; liA new microarray technology has found that ibrutinib, an old anticancer drug can target another cancer causing protein./li liIbrutinib can target potent cancer causing protein called ERBB4 kinanse./li liThis drug can block the sequence of events leading to progression and growth of other solid tumors./li/ul Using the new microarray technology, ibrutinib, an FDA approved anti-cancer drug has been found to target ...

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New Technology Helps Personalize Medicine  Voir?

A new method for the production of medicine has been developed. The medical drugs are printed in QR coded patterns onto an edible material that aid in personalizing medicine. For the last 100 years, researchers have constantly pushed the boundaries for our knowledge about medicine and how different bodies can respond differently to it. However, the methods for the production of medicine have not yet moved itself away from mass production. Many who have a given illness get the same product with equal amount of an active compound....

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Common Allergy Medication Reduces Relapses in Patients With Neuromyelitis Optica  Voir?

bBottom Line/b: The addition of cetirizine, a popular allergy medication sold under the brand name Zyrtec, to standard therapy is safe, well-tolerated, and may reduce relapses in patients with neuromyelitis optica (NMO), shows new study. NMO is a rare but severe disease that causes inflammation and demyelination, primarily in the optic nerve, spinal cord, and brainstem. bResults/b: The primary endpoint was the annualized relapse rate (ARR) while on the same disease-modifying therapy ...

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Difficulty in Breathing may Result from Opioid Addiction Medications  Voir?

bHighlights/b ul class=group-list punch-points liBuprenorphine, a drug used to treat opioid addiction can cause breathing problems in obese patients./li liBuprenorphine can impair breathing control in obese patients after tasks such as climbing stairs./li liBuprenorphine is used in opioid addiction treatment regime because it has lower abuse potential than methadone./li/ul Buprenorphine, a drug used to treat opioid addiction can cause breathing problems in obese patients finds a new study....

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When Precision Medicine Took a Biological Approach  Voir?

A novel precision medicine approach was used to manipulate genes using a self-assembling platform that delivers nucleic acids, such as small interfering RNAs (siRNAs), to distinct cell subsets. The new Tel Aviv University study published in iNature Nanotechnology/i discusses a new modular platform with a robust biological approach that may hold the key to the future of personalized medicine. The biological complexity of cancer and other diseases demands a more formidable arsenal of therapies ...

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Basal Cell Tumors Regrow when Patients Stop Drug Treatment  Voir?

Basal cell tumors tend to grow back when patients stop their drug treatment. The mechanism of action of drugs behind the recurrence of tumor has been identified, reveals a new study. Basal cell carcinomas are incredibly common somewhere between 1 million to 3 million diagnosed each year and rarely life-threatening. They're most often removed through surgery. But for a small minority of patients, they can be a bigger problem. In some cases, the cancer cannot be surgically removed, often because of where it's found....

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Novel Combination of Arthritis Drug and Light Therapy to Treat Vitiligo  Voir?

A novel combination therapy, an arthritis medication and light, was used to successfully restore skin color in vitiligo patients, shows study conducted by a team of Yale dermatologists published in iJAMA Dermatology/i. The study, led by associate professor of dermatology Brett King, M.D and his colleagues reported two cases of patients with significant loss of skin color from vitiligo, a chronic autoimmune disease that destroys skin pigment, leaving white splotches where there had been color....

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New Organ-on-a-chip Technology to Study Angiogenesis and Develop Anti-cancer Drugs  Voir?

A new organ-on-a-chip technology developed by research teams at the Institute of Industrial Science (IIS), the University of Tokyo, CNRS and INSERM help study the formation of blood vessel and the drugs that target this. The technology recreates a human blood vessel and shows how new capillaries grow from the parent vessel in response to biochemical signaling cues. The chip can further be used to develop drugs targeting angiogenesis as a therapeutic to treat cancer and blood-vessel-related diseases....

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Novel Antimicrobial Drug Helps to Prevent Tooth Decay  Voir?

Filling material with antimicrobial drugs have been designed to stop bacteria that dig under the tooth fillings and cause new cavities called recurrent cavities or caries. These recurrent cavities increase the patients visit to dentists and affect 100 million people every year that lead to an additional cost of US (Dollor) 34 billion to treat. The research was done by the Department of Materials Science (and) Engineering, Faculty of Dentistry, and the Institute of Biomaterials and Biomedical Engineering at the University of Toronto....

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Erectile Dysfunction may Not be Linked to Heart Medications  Voir?

bHighlights/b ul class=group-list punch-points liHeart medications may not have an adverse effect on erectile dysfunction as popularly believed./li liNone of the participants in the study experienced significant change in erectile function after taking cholesterol-lowering statins and blood-pressure lowering candesartan/HCTZ medications./li liDoctors can reassure patients to take these medications to prevent heart complications./li/ul Heart medications may not influence erectile dysfunction finds a new study....

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Bevacizumab Drug Shows Promising Results in the Treatment of Hemorrhagic Telangiectasia  Voir?

Hemorrhagic Telangiectasia (HHT) patients who treated with bevacizumab, intravenous injections reported a considerable decrease in nosebleeds, gastrointestinal bleeding. The drug was able to stop or considerably reduce the need of blood transfusions. The findings of this study are published in the IMayo Clinic Proceedings/I journal. The study provides good evidence for the excellent safety profile and efficacy of intravenous bevacizumab in the management of patients suffering from HHT . bHHT, ...

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Drug to Treat Heavy Bleeding may Prevent Maternal Deaths  Voir?

Tranexamic acid prevents blood loss after vaginal births and postpartum hemorrhage (PPH-major blood loss after labor and birth) among women who have an operative vaginal delivery (use of a vacuum or forceps) or an episiotomy (surgical cut made at the opening of the vagina during childbirth), finds a study. The study will be presented at the Society for Maternal-Fetal Medicine's (SMFM) annual meeting, The Pregnancy Meeting. Postpartum hemorrhage (PPH), the leading cause of maternal deaths worldwide ...

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India Working to Develop Anti-cancer Drug from Olives  Voir?

bHighlights/b ul class = "group-list punch-points" liNew anti-cancer drug can be developed from olives/li liRajasthan, a state in India attempts to extract triterpenoids from olive leaves and fruits/li liAgriculture department claims that olive has a chemical that can help fight against cancer/li/ul A new approach gives hope for cancer patients, as Agriculture department is making use of olives for developing anti-cancer drugs. In a recent report, the olivefruit was found to contain triterpenic acids (0....

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Novel Drug Combination Found To Be Highly Effective In Ewing Sarcoma  Voir?

bHighlights:/bul class="group-list punch-points"liCombination of CDK 12 (cyclin dependent kinase 12) inhibitor and PARP (poly ADP ribose polymerase) inhibitor shown to be very effective in controlling Ewing Sarcoma/liliEwing sarcoma is the second most common bone cancer in children and young adults but unfortunately is not very responsive to conventional chemotherapy/li/ul Novel combination of CDK inhibitor and PARP inhibitors have been found to be very ...

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Onion Extract may Help Develop New Drugs to Fight Drug-resistant TB  Voir?

bHighlights/b ul class = "group-list punch-points" li Persian shallots used in traditional Iranian cuisine has antibacterial properties. /li li The antibacterial properties were found to increase the effects of existing antibiotic treatment. /li li All four compounds which were synthesized from the shallots prevented the growth of multidrug-resistant tuberculosis bacteria by more than 99.9 %. /li/ul The antibacterial properties extracted from the Persian shallot could ...

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Access to Essential Medicines Still a Hurdle in India  Voir?

A shocking revelation of the lack of access to essential medicines in India, despite the approval of thousands in an attempt to generate wider availability has been reported by research teams at Newcastle University, UK and in Mumbai, India. The study published in iJournal of Global Health/i found that policy to open up the market has generated a large number of brands of medicines, but there are still not enough available in the pharmacies. This study assessed the rational use - those drugs ...

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Dernière mise à jour : 22/02/2018 @ 01:22

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